LAST CHANCE: Your year-end gift can be matched 4X.

Please hurry. Before midnight, make a year-end donation that can go 4X as far. Dear Tushar, Please don't wait. Before the clock strikes midnight and we say goodbye to 2021, I wanted to give you one last chance to QUADRUPLE your impact on the fight against Alzheimer's disease and make your final gift of the year go FOUR TIMES further to provide care and support and advance Alzheimer's research. This opportunity to have all gifts made by midnight matched 4X, up to a total of $150,000, is made possible by a generous donor who wishes to remain anonymous. As this year comes to an end, our friend has taken action and pledged their gift to the Tau Pipeline Enabling Program (T-PEP), a funding initiative to accelerate drug development breakthroughs that could help mitigate the toxic effects of tau protein "tangles" in the brain. Because tau tangles are implicated in a number of neurodegenerative disorders, the research made possible by T-PEP could potentially benefit individuals living with Alzheimer's, Parkinson's disease, frontotemporal dementia and more. Please don't miss this opportunity to have your gift before midnight tonight go 4X as far to support our mission to lead the way to end Alzheimer's and all other dementia — by accelerating global research, driving risk reduction and early detection, and maximizing quality care and support. Ring in the new year with hope for a world without Alzheimer's and with help for the more than 6 million Americans living with the disease. Please make your year-end gift now, while it can go 4X as far. With the year quickly winding down and transformative research being conducted all over the world, this is our moment to move closer toward our vision of a world without Alzheimer's and all other dementia. Please make your first gift before this amazing 4X match challenge ends at the stroke of midnight. All of us here at the Alzheimer's Association wish you a healthy and happy new year. Sincerely, Donna McCullough Chief Mission and Field Operations Officer P.S. Will you resolve to help fight Alzheimer's before the year ends? Your contribution before midnight can be matched 4X and will go directly to providing care and support and accelerating promising research. Thank you. Your donation will strengthen our efforts to advance Alzheimer's care, support and research. From face-to-face support to online education programs and promising global research initiatives, your gift makes a difference in the lives of all those affected by Alzheimer's and other dementias in your community and across the world. Thank you for your continued support. Alzheimer's Association Home Office, 225 N. Michigan Ave., Fl. 17, Chicago, IL 60601 © 2021 Alzheimer's Association. All rights reserved. 800.272.3900 | alz.org® | Donate Please add info@alz.org to your address book to ensure you receive all future emails.   Having trouble reading this email? View it in your browser   View your email preferences or unsubscribe.

⌛ Just hours left: Make 4X the impact before midnight.

Time is running out. Your year-end gift can be matched 4X. Dear Tushar, In just a few hours, 2021 will end — along with the opportunity to have your donation go an incredible 4X as far in the fight against Alzheimer's disease. Please make your first gift now, before this amazing offer ends at midnight. Tushar, we can't know what the next year will hold in terms of unpredictable challenges or unexpected discoveries. But here's what we know for sure: As the baby-boom population ages, the number of Americans living with Alzheimer's or another dementia will grow, which means the number of people providing unpaid care for people living with Alzheimer's will also increase. We must stand up and continue to move toward our vision of a world without Alzheimer's and all other dementia. To provide help and hope to all those impacted by this devastating disease, we need your support tonight. While some clink glasses at midnight, others will be wondering how they'll navigate an Alzheimer's diagnosis or will be feeling anxious about their family member in an assisted living community. Some will miss the joy of New Year celebrations because of a loved one who is no longer with them. Please know we're here for you if you need us. If you need support, information or guidance, don't hesitate to call to speak with one of our master's-level clinicians who staff our free 24/7 Helpline (800.272.3900) every hour of every day. This opportunity to have all gifts made by midnight matched 4X, up to a total of $150,000, is made possible by a generous donor who wishes to remain anonymous. They have pledged their gift to the Tau Pipeline Enabling Program (T-PEP), a funding initiative to accelerate drug development breakthroughs that could help mitigate the toxic effects of tau protein "tangles" in the brain. Will you accept this challenge to achieve this critical year-end match, and to help provide care and support while advancing global Alzheimer's research — moving us closer to a dementia-free future for generations to come? Please show your support now, before midnight, while you can still make a tax-deductible gift and QUADRUPLE your impact. Your gift of $16 can become $32 $64 until midnight tonight. Your gift of $30 can become $60 $120. And your very generous year-end donation of $50 can become $100 $200. Please help us start 2022 strong by giving now, while your gift can go 4X as far to further our mission to lead the way to end Alzheimer's and all other dementia — by accelerating global research, driving risk reduction and early detection, and maximizing quality care and support. Thank you in advance for making a New Year's resolution that you can keep before 2022 even begins. Your generosity on this night of celebration and hope can change countless lives. Sincerely, Donna McCullough Chief Mission and Field Operations Officer P.S. Our $150,000 4X Year-End Match Challenge ends in just a few hours. The clock is ticking — but if everyone reading this email contributes right now, we'll make our goal and take a tremendous step toward our vision of world without Alzheimer's and all other dementia. Please make your most generous gift while you can still quadruple your impact in the fight against Alzheimer's. Happy New Year, and thank you so very much. Your donation will strengthen our efforts to advance Alzheimer's care, support and research. From face-to-face support to online education programs and promising global research initiatives, your gift makes a difference in the lives of all those affected by Alzheimer's and other dementias in your community and across the world. Thank you for your continued support. Alzheimer's Association Home Office, 225 N. Michigan Ave., Fl. 17, Chicago, IL 60601 © 2021 Alzheimer's Association. All rights reserved. 800.272.3900 | alz.org® | Donate Please add info@alz.org to your address book to ensure you receive all future emails.   Having trouble reading this email? View it in your browser   View your email preferences or unsubscribe.

🕛 Quadruple your impact before the clock strikes midnight.

Today ONLY: 4X match Dear Tushar, I'm thrilled to report that just a few hours into our $150,000 4X Year-End Match Challenge, we've had a tremendous outpouring of support. But we really need the help of everyone in our Alzheimer's Association community to unlock this amazing match before midnight. Can you please take a moment and make a year-end gift now, while it can go 4X as far? Tushar, I know I don't have to tell you how remarkable a 4X match is — particularly today, the last day of 2021. Nor do I need to tell you that this is your last opportunity to make your year-end gift, which may be tax-deductible, to offer compassionate care and support to the more than 6 million Americans living with Alzheimer's disease. So instead, I'll tell you some of the phenomenal things we've accomplished over the last year. Thanks to the incredible support of our community, we were able to: Answer more than 220,000 calls through our 24/7 Helpline (800.272.3900), offering free confidential support and information to people facing Alzheimer's and all other dementia. Invest $70 million in Alzheimer's and dementia research, including more than $59 million in grants to 253 new scientific investigations. Advocate for an increase in Alzheimer's and dementia research at the National Institutes of Health (NIH) of $300 million, bringing federal funding to $3.2 billion annually. And I know that with you by our side, we'll achieve even greater things in 2022. In just a few hours, we'll ring in a new year — with both new opportunities and new challenges. Please help ensure we can provide high-quality care and support and accelerate global research through 2022 and beyond. Make your first gift now, while you can quadruple your impact on our work to offer help and hope to all affected by Alzheimer's. A generous donor who wishes to remain anonymous has pledged to quadruple-match every gift made before midnight tonight, up to a total of $150,000. Their gift will benefit the Tau Pipeline Enabling Program (T-PEP), a funding initiative to accelerate drug development breakthroughs that could help mitigate the toxic effects of tau protein "tangles" in the brain. Because tau tangles are implicated in a number of neurodegenerative disorders, the research made possible by T-PEP could potentially benefit individuals living with Alzheimer's, Parkinson's disease, frontotemporal dementia and more. If you share our donor's commitment to our fight, when you make a gift at this pivotal moment, you can make 4X the impact and make a significant difference in enhancing care and support and advancing research. And, you can even make your year-end gift as a tribute, in honor of a loved one. Can I count on you? Please make your year-end gift now, while it can go 4X as far. Happy New Year, and thank you for your commitment to our fight. Together, we will continue to further our mission to lead the way to end Alzheimer's and all other dementia — by accelerating global research, driving risk reduction and early detection, and maximizing quality care and support. With deep appreciation, Donna McCullough Chief Mission and Field Operations Officer P.S. Despite the challenges of this past year, our community stayed strong and united together. And our commitment to those living with Alzheimer's and their caregivers remains unwavering. Please help us end the year strong by donating before midnight, while your gift can still be matched 4X. Thank you. Your donation will strengthen our efforts to advance Alzheimer's care, support and research. From face-to-face support to online education programs and promising global research initiatives, your gift makes a difference in the lives of all those affected by Alzheimer's and other dementias in your community and across the world. Thank you for your continued support. Alzheimer's Association Home Office, 225 N. Michigan Ave., Fl. 17, Chicago, IL 60601 © 2021 Alzheimer's Association. All rights reserved. 800.272.3900 | alz.org® | Donate Please add info@alz.org to your address book to ensure you receive all future emails.   Having trouble reading this email? View it in your browser   View your email preferences or unsubscribe.

🎉 This 4X Year-End Match Challenge ends TODAY.

Quadruple your impact with your year-end gift now. Dear Tushar, I wanted to tell you as quickly as I could that we just received an unbelievable $150,000 4X Year-End Match Challenge, which means you have one more chance to make 4X the impact in the fight to end Alzheimer's. And given this is the last day of 2021, it couldn't come at a more perfect time — as we look ahead to a new year filled with promising research and potential new methods of treatment for Alzheimer's disease, and our continued commitment to providing care and support. Before midnight tonight, your generous gift can go FOUR times as far in the fight against Alzheimer's disease — and your gift may be tax-deductible for 2021. As the clock winds down on 2021, our community can be proud that, together, we kept up the momentum in the fight against Alzheimer's. And that despite the challenges of the past two years, the Alzheimer's Association continued to advance the best dementia science worldwide, while also providing care and support to all those who need it. Now, a generous donor who wishes to remain anonymous has pledged to quadruple-match ALL gifts, up to a total of $150,000, but only if we can meet this challenge by midnight tonight. Please hurry and make your gift today to provide care and support and advance vital research. Our friend was inspired to make this pledge and have their gift benefit the Tau Pipeline Enabling Program (T-PEP), a funding initiative to accelerate drug development breakthroughs that could help mitigate the toxic effects of tau protein "tangles" in the brain. Because tau tangles are implicated in a number of neurodegenerative disorders, the research made possible by T-PEP could potentially benefit individuals living with Alzheimer's, Parkinson's disease, frontotemporal dementia and more. Thank you for being part of our community. Before this day ends, will you please make your first donation while it can be matched 4X to bring us closer to our vision of a world without Alzheimer's and all other dementia? I'm counting on you to keep our work going strong in 2022. We are stronger together, and I know that if everyone reading this makes a year-end gift, we will achieve this match challenge and continue our work to end this devastating disease for our loved ones and friends living with Alzheimer's. By helping to unlock this $150,000 match challenge, you'll ensure urgently needed funds will go toward providing much-needed care and support and propelling research forward around the globe, as well as fortifying our advocacy efforts and increasing awareness. It's also the perfect way to honor a loved one, while providing help and hope to everyone facing this disease. Just look at how far your year-end gift can go: Your gift of $16 can become $32 $64 until midnight tonight. Your gift of $30 can become $60 $120. And your very generous year-end donation of $50 can become $100 $200. I appreciate all you've done to further our vital work, and I hope you'll take advantage of this final chance in 2021 to help advance our mission to lead the way to end Alzheimer's and all other dementia — by accelerating global research, driving risk reduction and early detection, and maximizing quality care and support. Thank you in advance for helping make this final match challenge of 2021 a success, and for giving us a head start on the new year. With your help, we'll continue to provide care and support and advance research toward methods of treatment, prevention and, ultimately, a cure. Happy New Year to you and yours, Donna McCullough Chief Mission and Field Operations Officer P.S. I'm truly grateful for all you've done to support our work. Please make your year-end gift, which may be tax-deductible, before midnight while every dollar you contribute can be matched 4X, up to a total of $150,000. Your donation will strengthen our efforts to advance Alzheimer's care, support and research. From face-to-face support to online education programs and promising global research initiatives, your gift makes a difference in the lives of all those affected by Alzheimer's and other dementias in your community and across the world. Thank you for your continued support. Alzheimer's Association Home Office, 225 N. Michigan Ave., Fl. 17, Chicago, IL 60601 © 2021 Alzheimer's Association. All rights reserved. 800.272.3900 | alz.org® | Donate Please add info@alz.org to your address book to ensure you receive all future emails.   Having trouble reading this email? View it in your browser   View your email preferences or unsubscribe.